In Ancient Greece, Orion had a hero cult in the region of Boeotia. The number of places associated with his birth suggest that it was widespread. Hyria, the most frequently mentioned, was in the territory of Tanagra. A feast of Orion was held at Tanagra as late as the Roman Empire.
They had a tomb of Orion most likely at the foot of Mount Cerycius (now Mount Tanagra). Maurice Bowra argues that Orion was a national hero of the Boeotians, much as Castor and Pollux were for the Dorians.He bases this claim on the Athenian epigram on the Battle of Coronea in which a hero gave the Boeotian army an oracle, then fought on their side and defeated the Athenians.
The Boeotian school of epic poetry was chiefly concerned with the genealogies of the gods and heroes; later writers elaborated this web. Several other myths are attached to Orion in this way: A papyrus fragment of the Boeotian poet Corinna gives Orion fifty sons (a traditional number). This included the oracular hero Acraephen, who, she sings, gave a response to Asopus regarding Asopus' daughters who were abducted by the gods. Corinna sang of Orion conquering and naming all the land of the dawn.] Bowra argues that Orion was believed to have delivered oracles as well, probably at a different shrine. Hyginus says that Hylas's mother was Menodice, daughter of Orion.
Another mythographer, Liberalis, tells of Menippe and Metioche, daughters of Orion, who sacrificed themselves for their country's good and were transformed into comets.
Orion also has etiological connection to the city of Messina in Sicily. Diodorus of Sicily wrote a history of the world up to his own time (the beginning of the reign of Augustus). He starts with the gods and the heroes. At the end of this part of the work, he tells the story of Orion and two wonder-stories of his mighty earth-works in Sicily. One tells how he aided Zanclus, the founder of Zancle (the former name for Messina), by building the promontory which forms the harbor. The other, which Diodorus ascribes to Hesiod, relates that there was once a broad sea between Sicily and the mainland. Orion built the whole Peloris, the Punta del Faro, and the temple to Poseidon at the tip, after which he settled in Euboea. He was then "numbered among the stars of heaven and thus won for himself immortal remembrance". The Renaissance historian and mathematician Francesco Maurolico, who came from Messina, identified the remains of a temple of Orion near the present Messina Cathedral.
Maurolico also designed an ornate fountain, built by the sculptor Giovanni Angelo Montorsoli in 1547, in which Orion is a central figure, symbolizing the Emperor Charles V, also a master of the sea and restorer of Messina;Orion is still a popular symbol of the city.
Images of Orion in classical art are difficult to recognize, and clear examples are rare. There are several ancient Greek images of club-carrying hunters that could represent Orion, but such generic examples could equally represent an archetypal "hunter", or indeed Heracles. Some claims have been made that other Greek art represents specific aspects of the Orion myth. A tradition of this type has been discerned in 5th century BC Greek pottery—John Beazley identified a scene of Apollo, Delian palm in hand, revenging Orion for the attempted rape of Artemis, while another scholar has identified a scene of Orion attacking Artemis as she is revenged by a snake (a counterpart to the scorpion) in a funerary group—supposedly symbolizing the hope that even the criminal Orion could be made immortal, as well as an astronomical scene in which Cephalus is thought to stand in for Orion and his constellation, also reflecting this system of iconography.Also, a tomb frieze in Taranto (ca. 300 BC) may show Orion attacking Opis. But the earliest surviving clear depiction of Orion in classical art is Roman, from the depictions of the Underworld scenes of the Odyssey discovered at the Esquiline Hill (50–40 BC). Orion is also seen on a 4th-century bas-relief, currently affixed to a wall in the Porto neighborhood of Naples. The constellation Orion rises in November, the end of the sailing season, and was associated with stormy weather, and this characterization extended to the mythical Orion—the bas-relief may be associated with the sailors of the city.